Remember, combining GLP-1 medications with lifestyle changes—such as healthy eating and increased physical activity—leads to sustained weight loss and better overall health. If you’re considering these medications, consult your doctor to see if they’re right for you!

GLP-1 medications can help manage blood sugar levels, reduce appetite, and support weight loss. However, they aren’t appropriate for everyone, and insurance coverage isn’t guaranteed. Medications known as glucagon-like peptide-1 receptor (GLP-1) agonists continue to rise in popularity thanks to their ability to help manage blood sugar levels and reduce hunger and food intake, thus potentially supporting weight loss.

The buzz around Semaglutide gained momentum following clinical trials that showcased its effectiveness in helping individuals achieve substantial weight loss. Studies have demonstrated that, when combined with lifestyle modifications, Semaglutide can lead to an average weight loss of 10-15% of body weight in individuals with obesity or overweight status. This finding has not only opened new avenues for tackling obesity but also positioned Semaglutide as a potential game-changer in addressing a condition that affects millions worldwide, contributing to various health issues, including heart disease, diabetes, and high blood pressure.

Semaglutide, a GLP-1 receptor agonist, has been a beacon of hope for those struggling with obesity. By mimicking the action of an intestinal hormone that induces insulin release, it not only aids in blood sugar management but also suppresses appetite, leading to significant weight loss. Its approval for weight management heralded a new era in obesity treatment, offering a viable, long-term solution for millions.

However, these medications, including Ozempic and Zepbound, aren’t for everyone and can be pretty expensive, especially if you have to pay for them out of pocket. Compounded Semaglutide is a custom-made medication created by specialized pharmacies when FDA-approved medications like Ozempic or Wegovy are in short supply, and as an alternative treatment that is substantially less money! These two injectable medications contain semaglutide, a glucagon-like peptide-1 (GLP-1) agonist used for weight management and type 2 diabetes.

GIP medications and GLP-1 medications both play a role in controlling blood sugar, but they have distinct functions:

GLP-1 (Glucagon-Like Peptide-1) Agonists:

• Used for Type 2 diabetes management.
• Trigger insulin release, reduce glucose production, and promote fullness.
• Examples: Ozempic and Wegovy (semaglutide).
• Some cause weight loss as a side effect.
• Wegovy is a higher-dose version specifically approved for weight loss.

GIP (Gastric Inhibitory Peptide) Medications:

• Mimic GIP, another gut hormone.
• May prevent fat storage.

Dual agonists (targeting both GLP-1 and GIP receptors) are being explored. In summary, GLP-1 focuses on blood sugar and appetite, while GIP may have additional effects on fat metabolism.

Tirzepatide is a medication used for both weight loss and type 2 diabetes management. Here’s how it works:

Weight Loss:

• Decreases appetite and slows food movement from the stomach to the small intestine.
• Administered as a once-weekly injection under the skin.
• FDA-approved for adults with obesity or those who are overweight with weight-related issues.
• Combine with diet and exercise for best results.

Type 2 Diabetes:

• Improves blood sugar levels by:
• Releasing insulin when blood sugar is high.
• Reducing liver sugar production.
• Slowing food movement through the intestines.
• Use with diet and exercise.
• Not for type 1 diabetes patients.

Both Mounjaro (for diabetes) and Zepbound (for weight loss) contain tirzepatide and are made by Eli Lilly and Company.

What If You Hit A Weight Loss Plateau?

Fear Not! Monica Amin, PharmD at Marley Drugs offers these strategies...

"Adjusting Dosage
Sometimes, the effectiveness of a weight loss medication can be enhanced by adjusting its dosage. This might involve increasing the dose within safe limits or altering the frequency of administration. If your current regimen isn't yielding results, your doctor might suggest these changes.

"Switching Medications
If you find that your progress has stalled with your current medication, your doctor may recommend switching to a different weight loss drug that operates differently. This strategy can sometimes reactivate weight loss if your body has adapted to the current medication.

"Lifestyle Modifications
Weight loss medications are most effective when combined with lifestyle modifications. Despite the assistance these medications provide in managing hunger, they are not standalone solutions. Clinical trials often include dietary and exercise advice, underscoring the importance of these elements in overall weight management.

Diet
Review and possibly overhaul your diet to ensure it aligns with your weight loss goals. Working with a registered dietitian or nutritionist can be particularly beneficial in optimizing your eating plan.

Exercise:
Enhancing your exercise regimen can boost calorie burn and improve overall fitness. Consider incorporating a variety of physical activities that you enjoy, as this can help maintain motivation and effectiveness.

"Speak With Your Doctor
If you've hit a plateau in weight loss while taking any weight loss medication, the first step is to consult with your healthcare provider. They can evaluate your progress, assess whether adjustments to your medication regimen are necessary, and provide guidance based on your specific situation."